International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2015, Volume : 3, Issue : 6
First page : (156) Last page : (167)
Article doi: http://dx.doi.org/10.18782/2320-7051.2161

Absence of adverse toxic effects of Cardoguard, an Ayurvedic anti-hypertensive formulation, in sub-acute toxicity evaluation in rats

P. Yuvaraj, Therasilin Louis and V. Madhavachandran*
Experimental Pharmacology Unit, Nagarjuna Herbal Concentrates Ltd, Alakkode, kalayanthani P.O.,
Thodupuzha, Idukki, Kerala-685 588, INDIA
*Corresponding Author E-mail: dr.therasilin@gmail.com
Abstract
Cardoguard, an ayurvedic polyherbal medicine, currently used for hypertension, showed efficacy in experiments on rats. Further, recent studies have shed light on its mechanism of action. The formulation containing 6 traditional medicinal plants as ingredients was not subjected to toxicity evaluation under controlled conditions. Therefore, in the present study, a sub-acute toxicity evaluation was carried out. The sub-acute toxicity study (29 days) in rats did not show any toxic symptoms at 25 mg/kg (which is 4 times higher than the extrapolated therapeutic dose) of Cardoguard as judged from serum biochemical parameters, hematological parameters, behaviour of animals, weight as well as histology of liver, kidneys and heart. However, a marginal decrease in body weight of female rats was observed. At very high doses (50 and 100 mg/kg) serum protein (albumin and globulin) decreased. At these doses, total cholesterol and LDL cholesterol were also decreased in male and female rats which are considered as beneficial effects. In male rats alone, at 100 mg/kg group a small statistically significant decrease in serum urea was observed. Thus the formulation appears to be very safe.

Key words: Cardoguard, Herbal-formulation, Anti-hypertension, Rats. Toxicity

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Yuvaraj, P., Louis, T. and Madhavachandran, V., Absence of adverse toxic effects of Cardoguard, an Ayurvedic anti-hypertensive formulation, in sub-acute toxicity evaluation in rats, Int. J. Pure App. Biosci. 3(6): 156-167 (2015). doi: http://dx.doi.org/10.18782/2320-7051.2161