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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2017, Volume : 5, Issue : 2
First page : (277) Last page : (281)
Article doi: http://dx.doi.org/10.18782/2320-7051.2926

A New Cytotoxic Chromen-C-Glucoside from the Leaves of Salvadora persica

Samy K. El-Desouky1,2*, Habib Khemira3 and Ahmed A.M. Abdlgawad4
1Chemistry Department, Faculty of Science, Jazan University, 2097-Jazan, Saudi Arabia
2Phytochemistry and Plant Systematics Department, National Research Centre, Dokki-12311, Cairo, Egypt
3Centre for Environmental Research and Studies, Jazan University, 82817- Jazan, Saudi Arabia
4Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt
*Corresponding Author E-mail: desoky5@hotmail.com
Received: 18.04.2017  |  Revised: 28.04.2017   |  Accepted: 30.04.2017  


The phytochemical investigation of the methanolic extract of the leaves of Salvadora persica afforded five known compounds identified as kampferol-3-O-β-glucopyranoside, Kaempferol-3,7-di-O-β-glucopyranoside, quercetin-3',7-dimethylether, isobiflorin (5,7–dihydroxy-2-methylchromone-8-C-β-glucopyranoside), biflorin (5,7–dihydroxy-2-methylchromone-6-C-β-glucopyranoside), as well as a new cytotoxic chromen derivative; 5-hydroxy-7-methoxy-2-methyl-4H-chromen-4-one-6-C-glucopyranoside. The structure characterization of the isolated compounds was based on MS and NMR spectral data. The cytotoxic activity of the new chromen glycoside was investigated against several cancer cell lines such as Hep-G2, MCF-7, MDA-MB-231 and HT-29. The compound exhibited a cytotoxic activity against Hep-G2, whereas the activity was not significant against MCF-7, MDA-MB-231 and HT-29 cells.

Key words:  Salvadora persica,Chromen-C-glycoside, Cytotoxicity, NMR

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: El-Desouky, S.K., Khemira, H. and Abdlgawad, A.A.M., A New Cytotoxic Chromen-C-Glucoside from the Leaves of Salvadora persica, Int. J. Pure App. Biosci.5(2): 277-281 (2017). doi: http://dx.doi.org/10.18782/2320-7051.2926