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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2017, Volume : 5, Issue : 2
First page : (31) Last page : (42)
Article doi: http://dx.doi.org/10.18782/2320-7051.2421

Renoprotective and Antioxidant Effects of Silymarin and Propolis on Diclofenac Sodium - Induced Renal Toxicity in Rats

Kamal Adel Amin1*, Rasha Rashad Ahmed2, Walaa G. Hozayen3,4 and Aziza Antar3
1Biochemistry Department, Faculty of Veterinary Medicine, Beni-Suef University, Egypt
1Chemistry Department, College of Science, University of  Imam Abdulrahman Alfaisal, KSA
2Zoology Department, Faculty of Science, Beni-Suef University, Egypt
3Chemistry Department, Biochemistry Branch, Faculty of Science, Beni-Suef University, Egypt,
4Biotechnology & life science department, Faculty of postgraduate studies for advanced Sciences (PSAS),
Beni-Suef University, Egypt
*Corresponding Author E-mail: kaothman@uod.edu.sa
Received: 16.12.2016  |  Revised: 2.01.2017   |  Accepted: 5.01.2017  


Diclofenac (DCL) is used to treat painful and inflammatory rheumatic and non-rheumatic conditions. Our aim was to assess the possible protective role of silymarin and propolis against DCL-induced renal damage. DCL sodium (75mg/kg b.wt) was administered orally with or without silymarin (250 mg/kg b.wt) or propolis (8.4 mg/kg b.wt) co-treatment for one month in adult male rats. Serum creatinine, urea, uric acid, renal glutathione, renal glutathione transferase, and lipid peroxidation were assessed. There were significant increases in serum levels of creatinine, urea, and uric acid. Also, renal glutathione and glutathione transferase activities were reduced, but the lipid peroxidation levels in the kidneys increased in DCL group. The administration of silymarin and propolis greatly reduced the adverse changes in the kidney function by raising antioxidant activities and reducing lipid peroxidation. In conclusion, silymarin and propolis may provide natural protection against renal toxicity caused by DCL sodium.

Keywords:Silymarin, propolis, antioxidant, diclofenac, renal toxicity

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Amin, K.A., Ahmed , R.R., Hozayen, W.G. and Antar, A., Renoprotective and Antioxidant Effects of Silymarin and Propolis on Diclofenac Sodium - Induced Renal Toxicity in Rats, Int. J. Pure App. Biosci.5(2): 31-42 (2017). doi: http://dx.doi.org/10.18782/2320-7051.2421