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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2017, Volume : 5, Issue : 6
First page : (14) Last page : (18)
Article doi: http://dx.doi.org/10.18782/2320-7051.5996

Antifungal Activity of Leptadenia hastata (Pers) Decne Leaves Extract

Isaac John Umaru1, Fasihuddin A. Badruddin1, Zaini B. Assim1
and Hauwa Aduwamai Umaru2
1Faculty of Resource Science and Technology, University of Malaysia Sarawak, Kuching, 94300, Kota Samarahan Malaysia
2Department of biochemistry, Modibo Adama University of Technology Yola Adamawa state. Nigeria
*Corresponding Author E-mail: umaruisaac@gmail.com
Received: 13.11.2017  |  Revised: 20.12.2017   |  Accepted: 26.12.2017  


Objective: The aim of this study was to investigate the antifungal activities of the hexane extract of Leptadenia hastata. The Concern has been expressed about the rising prevalence of pathogenic microorganisms which are resistant to the modern antimicrobial drugs as such the search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethno pharmacologists, biochemist, botanists, microbiologists and natural product scientists are combing the earth for phytochemicals and leads which could be developed for treatment of infectious diseases. Materials and method: the fungal activities of the extract at various concentration were performed by agar diffusion method, DMSO as negative control while Fluconazole as positive control for five days. One way ANOVA was used to determine the statistical difference between three mean inhibition value at significance P<0.005. Result: The concentration of extract at day four and five, 25ppm, 50ppm and 100ppm showed the highest activities against Aspergillus flavus and Aspergillus niger. While the inhibition of Candida tropicallis, and Fusarium oxysporium was very slow when compared with the other two at the same concentration same days. The activity of the extracts was determined against different pathogenic fungi including. Aspergillus flavus, Aspergillus niger, Candida tropicallis, and Fasarium oxysporium.  Extracts at 50ppm and 100ppm were the most effective followed by 500ppm which showed moderate activities. The lowest activity was recorded for 1000ppm. The Four fungi differed with regard to their susceptibility to the plant concentration per days. Aspergillus niger, was the most susceptible, followed by Aspergillus Flavin, Candida tropicallis and Fusarium oxysporium, respectively. Conclusion: the study indicate that hexane extracts at a given concentration possess an antifungal potential which is effective at 25ppm, 50ppm and 100ppm, hence should be used to treat infections with pathogenic fungi.

Key words: Antifungal, Diflucan, Leptadenia hastata, Dimethyl sulfoxide

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Umaru, I. J., Badruddin, F.A., Assim, Z.B. and Umaru, H.A., Antifungal Activity of Leptadenia hastata (Pers) Decne Leaves Extract, Int. J. Pure App. Biosci.5(6): 14-18 (2017). doi: http://dx.doi.org/10.18782/2320-7051.5996