International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 2
First page : (47) Last page : (56 )
Article doi : http://dx.doi.org/10.18782/2320-7051.6338

Quorum Sensing Inhibition Bioactivities of Philippine Ethnobotanicals against Pseudomonas aeruginosa

Gene Beniece B. Limos¹*, Khristina G. Judan Cruz¹ and Wilson R. Jacinto²

¹Department of Biological Sciences, Central Luzon State University,
Science City of Muñoz, Nueva Ecija, Philippines
²Biological Sciences Department, De La Salle University - Dasmariñas, City of Dasmariñas, Cavite, Philippines
*Corresponding Author E-mail: bnice_1706@yahoo.com

Received: 15.03.2018 | Revised: 18.04.2018   | Accepted: 23.04.2018

 ABSTRACT

The quorum sensing inhibition (QSI) activities of ethanolic extracts of selected Philippine ethnobotanicals against Pseudomonas aeruginosa BIOTECH 1335 were evaluated in the study. Ethnobotanicals tested were Bidens pilosa L. (Anwad), Cestrum nocturnum L. (Dama de Noche), Sarcandra glabra (Thunb.) Nakai (Hag-ob), Oreocnide trinervis (Wedd.) Miq. (Lal-latan), Derris elliptica Benth. (Opay), Alstonia scholaris (L.) R. Br. (Palay), Ageratina adenophora (Spreng.) R. M. King & H. Rob (Panawel) and Ayapana triplinervis (Vahl) R. M. King & H. Rob (Pantallion).Ethanolic extracts were subjected to assays on the phenotypic expression of virulence factors for P. aeruginosa: pyocyanin production and swarming motility.The ethanolic extracts of O. trinervis, C. nocturnum and A. triplinervis showed presence of QSI in both virulence assays of P. aeruginosa; whereas the ethanolic extracts of S. glabra, D. elliptica, A. scholaris and A. adenophora showed presence of QSI only on the swarming motility but not in pyocyanin production. All ethanolic extracts of the ethnobotanicals showed great potential in the development of anti-quorum sensing drugs as new strategy to combat bacterial infections and inhibition of quorum sensing related virulence processes.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Limos, G.B.B., Judan Cruz, K.G. and Jacinto, W.R., Quorum Sensing Inhibition Bioactivities of Philippine Ethnobotanicals against Pseudomonas aeruginosa, Int. J. Pure App. Biosci.6(2): 47-56 (2018). doi: http://dx.doi.org/10.18782/2320-7051.6338