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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 5
First page : (1310) Last page : (1317)
Article doi: :

Anatomical and Clinical Perspective of APUD Cell Series: An Overview

Arun Kumar Mandal* and Nirmal Kumar Tudu

Department of Veterinary Anatomy & Histology, Faculty of Veterinary &Animal Sciences,
West Bengal University of Animal & Fishery Sciences, Kolkata, West Bengal
*Corresponding Author E-mail:
Received: 27.07.2018  |  Revised: 30.08.2018   |  Accepted: 7.09.2018



APUD system (Amine Precursor Uptake and Decarboxylation) encompasses a wide range of endocrine cell types scattered throughout the body like respiratory system, gastro-enteropancreatic system, reproductive system, thyroid gland, pancreatic islets, adrenal medulla, carotid body, kidney, pituitary gland etc. The APUD cell family now includes around 40 members. The APUD concept has more popularly been replaced by ‘diffuse neuroendocrine system (DNES)’ in recent past. These cells release their secretion into blood (endocrine secretion) or have paracrine effect on the neighboring cells. The diffuse neuroendocrine system can regulate the activities of immune system also. Clinical importance of these diffuse populations of endocrine cells is well established. Neural crest origin of the endocrine polypeptide (APUD) cells was earlier proposed. However, endodermal, mesodermal and even epidermal origin of many such cells are also suggested. Several histological methods are employed for demonstration of neuroendocrine (APUD) cells. Many special light microscopic staining techniques are still useful for identification of these cells. Electron microscopic (TEM) and immunohistochemical techniques, specially the latter ones are by far the best in this regard. Thorough knowledge of APUD cells would be of paramount importance to better understand their functional significance specifically in respect to growth of broiler chicken and neuro- endocrinological pathology.

Key words: APUD cells, Distribution, Identification, Importance, Origin

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Cite this article: Mandal, AK. and Tudu, N.K., Anatomical and Clinical Perspective of APUD Cell Series: An Overview, Int. J. Pure App. Biosci.6(5): 1310-1317 (2018). doi: