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International Journal of Pure & Applied Bioscience (IJPAB)
Year : 2018, Volume : 6, Issue : 5
First page : (20) Last page : (27)
Article doi: :

Gastroprotective Effect of Leptadenia Hastata (Pers.) Decne and Histopathological Changes on Indomethacin-Induced Gastric Ulcer in Rats

Isaac John Umaru1,2, Fasihuddin A. Badruddin1 and Hauwa A. Umaru3

1Faculty of Resource Science and Technology, University of Malaysia Sarawak, Kuching,
94300 Kota Samarahan Malaysia
2Department of Biochemistry, Federal university wukari, Taraba State
3Department of Biochemistry, Modibo Adama Federal University Technology Adamawa State
*Corresponding Author E-mail:
Received: 13.08.2018 | Revised: 29.09.2018 | Accepted: 5.10.2018



Objectives: Ulcer induced rats has been largely investigated, but gastro protective effect of Leptadenia hastata (Pers.) Decne and histopathological changes on indomethacin-induced gastric ulcer in rats was lacking thus, the ulcer score and percentage protection was calculated from the stomach and histopathological study of the ulcer stomach was performed. Material and Method: The effect of methanol root extract were studied in 40 albino rats over a period of 21days, the rats were divided into eight groups, those in group one served as the control, group two as the negative control (Indomethacin), group three as the positive control (Omeprazole) and group four to eight are dosed ranged groups from 100-500mg/kg extract. Tissue injury and its infiltration were examined and scored, the length and breadth of the lesion were measured for ulcer index. Results: Inflammatory and fibrosis alteration were present in ulcer treated rats, at days 21 colonic wall thickening and fibrotic remodelling were evident as well as blood vessels remodelling. The percentage rate of healing was 87.23% at 500ppm, 62.11% at 400ppm, 52.34% at 300ppm and 32.77% at 200ppm when compared to the control (93.60%). The present findings provide an integrated view of ulcer healing processes occurring in the ulcer induced colonic compartment of rats induced by indomethacin. These ulcerogenic alteration may represent a suitable basis for understanding the effects of Leptadenia hastata Methanol crude extract to ulcer treatment.

Key words: Leptadenia hastata, Histopathology, Indomethacin, Haematoxylin, Eosin, Omeprazole.

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Cite this article: Umaru, I. J., Fasihuddin, A., Badruddin and Hauwa, A., Umaru, Gastroprotective Effect of Leptadenia Hastata (Pers.) Decne and Histopathological Changes on Indomethacin-Induced Gastric Ulcer in Rats, Int. J. Pure App. Biosci.6(5): 20-27 (2018). doi: