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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2019, Volume : 7, Issue : 4
First page : (298) Last page : (309)
Article doi: :

microRNA: An Advance Diagnostic Approach in Tuberculosis

Aditya Upadhyay1, Anmol Kulshrestha1, Gopal Patel1, Mritunjai Singh1, Deepika Gupta2 and Sandeep K. Shrivastava2*
1School of Biotechnology – Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Road, Bhopal, 462033, India
2Centre for Innovation Research and Development (CIRD), Dr. B. Lal Clinical Laboratories Pvt. Ltd.,
Dr. B. Lal Institute of Biotechnology Jaipur, 302017, India
*Corresponding Author E-mail:
Received: 5.07.2019  |  Revised: 16.08.2019   |  Accepted: 24.08.2019  


Tuberculosis is the worldwide lethal infectious disease at current days, which is caused by Mycobacterium tuberculosis. microRNA is a small non coding RNA molecule that plays a key role in regulating various biological process. Host microRNA themselves can be up-regulated or down-regulated during disease condition. Potential unique host microRNA might be used as a biomarker in tuberculosis diagnosis at an earlier stage. Therefore, potential host microRNA recognition must be useful in tuberculosis in term of diagnostic purpose. miRNA biomarker field requires more comprehensive work in tuberculosis disease. This review summarizes the biogenesis and biological function of microRNA and various previous and recent studies on recognition of potential biomarker for tuberculosis in case of latent and active tuberculosis. This review also summarizes the role of specific host microRNA in tuberculosis.

Keywords: microRNA, Biogenesis, Tuberculosis, Biomarker.

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Cite this article: Upadhyay, A., Kulshrestha, A., Patel, G., Singh, M., Gupta, D., & Shrivastava, S.K. (2019). microRNA: An Advance Diagnostic Approach in Tuberculosis, Ind. J. Pure App. Biosci. 7(4), 298-309. doi: