INDIAN JOURNAL OF PURE & APPLIED BIOSCIENCES

ISSN (E) : 2582 – 2845

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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2019, Volume : 7, Issue : 4
First page : (329) Last page : (340)
Article doi: : http://dx.doi.org/10.18782/2320-7051.7726

Expression and Regulation of microRNAs in Tuberculosis: A Review

Anmol Kulshrestha1, Aditya Upadhyay1, Gopal Patel1, Suresh K. Jatawa1, Deepika Gupta2, Sandeep K. Shrivastava2*
1School of Biotechnology – Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Road, Bhopal, 462033, India
2Centre for Innovation Research and Development (CIRD), Dr. B. Lal Institute of Biotechnology, Dr. B. Lal Clinical Laboratories Pvt. Ltd., Jaipur, 302017, India
*Corresponding Author E-mail: ssk.cird1@gmail.com
Received: 7.07.2019  |  Revised: 18.08.2019   |  Accepted: 27.08.2019  

 ABSTRACT

Several diagnostic tools and techniques are available for the diagnosis of tuberculosis (TB) but these techniques shown an inadequate response in early diagnosis of tuberculosis and hence they have low sensitivity and specificity. Also, these techniques have some inaccuracy in the diagnosis of different forms of tuberculosis such as pulmonary/extra-pulmonary tuberculosis and active/latent tuberculosis. From the previous studies in various diseases such as cancer and cardiac diseases, microRNAs (miRNAs) shows the remarkable growth due to their reliable and stable nature in the circulating fluid of the body. This review focused on the role of various miRNAs in the host during the Mycobacterium tuberculosis infection and the miRNA’s efficiency to act as a potential biomarker for the diagnosis of tuberculosis in the cases such as Active/Latent Tuberculosis, Pulmonary/Extra-Pulmonary Tuberculosis. Immunological aspects and miRNA regulation during the tuberculosis infection were also discussed in this review.

Keywords: miRNA, Tuberculosis, Biomarker, Diagnosis, Mycobacterium tuberculosis, Up-regulation, Down-regulation, Therapeutic target.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Kulshrestha, A., Upadhyay, A., Patel, G., Jatawa, S.K., Gupta, D., & Shrivastava, S. K. (2019). Expression and Regulation of microRNAs in Tuberculosis: A Review, Ind. J. Pure App. Biosci. 7(4), 329-340. doi: http://dx.doi.org/10.18782/2320-7051.7726




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