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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2019, Volume : 7, Issue : 6
First page : (29) Last page : (41)
Article doi: : http://dx.doi.org/10.18782/2582-2845.7900

An Insight Review on Application of Plantibodies

Hiwot Tilahun¹, Guesh Negash¹ and Haben Fesseha^2*
1College of Veterinary Medicine, Mekele University, PO box 2084, Mekelle, Ethiopia
²School of Veterinary Medicine, Wolaita Sodo University, PO box 138, Wolaita Sodo, Ethiopia
*Corresponding Author E-mail: tseyon.h@gmail.com
Received: 8.11.2019  |  Revised: 14.12.2019   |  Accepted: 20.12.2019  

 ABSTRACT

A plantibody is an antibody produced by plants that have, as well as the advantage, challenge, and limitation of plantibodies, with animal genes. The term “Plantibodies” was created to describe the products of plants that have been genetically modified to express antibodies and antibody fragments in plants. Productions of plantibodies offer several advantages over other methods of antibody production, such as low cost of production, high yield of antibodies, safe and effective approach and bring the product to the market within a short time. Six plant-derived antibodies have been developed as human therapeutics, two of which have reached phase II clinical trials. Agricultural crops such as tobacco, tomato, potato, soya bean, alfalfa, rice, and wheat are commonly used for the production of plantibodies. These plantibodies are formed by various methods like conventional method, cell tissue culture method, breeding, and sexual crossing, transgenic seeds, targeting and compartmentalizing. Plantibodies are now used for large scale medical and veterinary sectors for the treatment of immune disorders, cancers, inflammatory diseases, for the production of vaccines and also for diagnostic purposes. This review highlights the methods of production and application of plantibodies as well as the various types of pharmaceutical antibodies produced in transgenic plants. Hence, scholars should promote their application and use in the field of human and veterinary medicine.

Keywords: Antibody; Application; Plantibody; Production; Transgenic plant

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Tilahun, H., Negash, G., & Fesseha, H. (2019). An Insight Review on Application of Plantibodies, Ind. J. Pure App. Biosci. 7(6), 29-41. doi: http://dx.doi.org/10.18782/2582-2845.7900