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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 1
First page : (92) Last page : (96)
Article doi: : http://dx.doi.org/10.18782/2582-2845.7819

Evaluation of Antiangiogenic Activity Artocarpus heterophyllus Extract by Sponge Implantation Method in Mouse

Upase Abhijeet P.¹, B. C. Ghumare^2*, Vikas. V. Karande³, V. R. Patodkar⁴,
V. S. Dhaygude⁵, and S. B. Lambate^6
1PG Scholar, Department of Veterinary Pharmacology and Toxicology,
^2*,3Assistant Professor, Department of Pharmacology and Toxicology,
⁴Associate Professor, Department of Physiology,
⁵Assistant Professor, Department of Pathology,  
KNPCVS, Shirwal, Satara-412801, Maharashtra, India
⁶Assistant Professor, Department of Anatomy, KNPCVS, Shirwal Dist- Satara,
Bombay Veterinary College, Parel, Mumbai -400012, India
*Corresponding Author E-mail: bcghumare@gmail.com
Received: 22.10.2019  |  Revised: 25.11.2019   |  Accepted: 29.11.2019 

 ABSTRACT

The present research work was conducted in department of Veterinary Pharmacology and Toxicology, Krantisinh Nana Patil College of Veterinary Science, Shirwal. The study was conducted in 18 male swiss albino mice divided into three groups comprising of six animals in each.  All the animals were subjected to subcutaneous implantation of gel foam sponges. Group I was kept as a control (blank sponge), group II received sponge with SU5416 (25mg/kg) and group III received sponge treated with extract of Artocarpus heterophyllus (300 mg/kg body weight). On 14th day animals were sacrificed and gel foam sponges were collected for estimation of haemoglobin, VEGF and histopathological examination. The mean (±SE) haemoglobin concentration (µg/mg weight of sponge) in mice were 1.918 ± 0.087 in untreated group, 0.365 ± 0.031 in positive control group, 0.672 ± 0.038 in Artocarpus heterophyllus extract treated group. The mean (±SE) VEGF concentration (pg/mg weight of sponge) in groups I to III of mice were 2.369 ± 0.198, 0.562 ± 0.074, 0.794 ± 0.148 respectively.The MVD (±SE) per field from processed sponges in groups I to III of mice were14 ± 2.84, 1 ± 0.36, 4 ± 0.93 respectively.From the present findings it is observed that Artocarpus heterophyllus showed anti-angiogenic effect equals to standard angiogenic inhibitor drug. Further extensive studies are required for assessing the utility of Artocarpus heterophyllus in clinical set-ups.

Keywords: SU5416, Artocarpus heterophyllus, VEGF, MVD, Haemoglobin.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Abhijeet, U.P., Ghumare, B.C., Karande, V.V., Patodkar, V.R., Dhaygude, V.S., & Lambate, S.B. (2020). Evaluation of Antiangiogenic Activity Artocarpus heterophyllus Extract by Sponge Implantation Method in Mouse, Ind. J. Pure App. Biosci. 8(1), 92-96. doi: http://dx.doi.org/10.18782/2582-2845.7819