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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 2
First page : (238) Last page : (247)
Article doi: : http://dx.doi.org/10.18782/2582-2845.8029

Modulatory Effects of Ginkgo biloba in Cyclophosphamide Induced Genotoxicity in Germ Cells of Mice

Ravi Prasad A.^1* and Rudrama Devi K.^2
1Asst. Prof. of Zoology, ABV Govt. Degree College Jangaon, Telangana
²Depart. of Zoology UCS, Osmania University, Telangana, India
*Corresponding Author E-mail: raviprasadzoology@gmail.com
Received: 13.03.2020  |  Revised: 16.04.2020   |  Accepted: 20.04.2020 

 ABSTRACT

Cyclophosphamide  has  been  used  for  treatment  of  various cancers,   hence  there are side  toxic effects has  been noted hence  studies were  carried  to  evaluate  the protective  effects of  Ginkgo biloba in  germ cells  of  mice   two experiments  were  carried  out. In first experiment the animals were treated with various doses of GBE 200, 400 and 600 mg/kg were given orally. All the animals were killed on 60th day if treatment for meiotic prepares were made according to the standardized protocol.  In second experiment  animals  were  given   Cyclophosphamide co  administered  with GBE   for  seven days  prior  to the  cp .   the  prepared  slides  were screened  for  the  presence  of  various  types  of  aberrations  such  as  autosomal univalent  and  sex chromosomal  univalent  and  translocations  in  control   and  treated  animals . the  data  was  analyzed  using standard  statistical  analysis    the  results  showed  increased  incidence of  chromosomal aberration in cp induced  animals however  in primed  with  GBE  there is  a  significant  reduction  in the  frequency  of  aberrations   thus  the  data  clearly  indicate  protective  nature  of  Ginkgo biloba  in  Swiss albino  mice  the present  observations  are  useful  in ca cancer chemotherapy  regimen.

Keywords:  Cyclophosphamide, Ginkgo Biloba Extract, Chromosomal Aberrations, Germ Cells 

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Ravi Prasad, A., & Rudrama Devi, K. (2020). Modulatory Effects of Ginkgo biloba in Cyclophosphamide Induced Genotoxicity in Germ Cells of Mice, Ind. J. Pure App. Biosci. 8(2), 238-247. doi: http://dx.doi.org/10.18782/2582-2845.8029