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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2020, Volume : 8, Issue : 3
First page : (114) Last page : (122)
Article doi: : http://dx.doi.org/10.18782/2582-2845.7923

Role of Comorbidities in Establishment of Pulmonary Mycosis in Chronic Obstructive Pulmonary Disease Patients in and Around Rewa

Samta Shukla^1* and C. B. Shukla^2
1*Centre for Biotechnology/Microbiology Studies, APS University Rewa, M.P.
²S.S. Medical College, Rewa, M.P.
*Corresponding Author E-mail: skantk@hotmail.com
Received: 14.01.2020  |  Revised: 23.02.2020   |  Accepted: 3.03.2020 

 ABSTRACT

Background: Viruses and bacterias have been already considered as a major cause of chronic obstructive pulmonary disease (COPD) exacerbations; whereas, the major role of fungal colonization and infection is poorly understood.
Objective: Keeping this fact in mind the present study was designed to find out the microbes responsible for acute exacerbation of COPD, which is one the common disorder of chronic lung disease in and around Rewa along with the profile of pulmonary fungal infection among COPD patients with and without comorbidities to determine their prevalence, risk factors, and outcome among those patients.
Patients and methods: In this prospective cross-sectional analytic study, different samples (sputum , bronchoalveolar lavage, blood, and others) from 180 COPD patients at risk for pulmonary fungal infection were examined using mycological analysis (direct microscopy with lactophenol cotton blue and culture in SDA media). Broncho alveolar lavage and blood samples were examined using the human 1,3-β-d-glucan and galactomannan ELISA tests.
Results: The prevalence of pulmonary fungal infection was significantly higher in COPD patients with comorbidities (77.5%) whereas COPD patients without comorbidities (53%) (P < 0.001),  with a predominance of Candida and Aspergillus spp. in both  groups. Mechanical ventilation, corticosteroid therapy, ICU admission and age were major risk factors for pulmonary fungal infection in COPD patients with comorbidities [P = 0.013, odds ratio (ODR) = 2.24; P = 0.029, ODR = 2.02; P = 0.024, ODR = 1.98; and P = 0.036, ODR = 2.64; respectively]. COPD patients with comorbidities had significantly higher mortality rate (13.8%) compared with COPD patients without comorbidities (3.6%; P < 0.05). Blood galactomannan antigen was positive in 19 (10.5%) COPD patients with comorbidities versus 8 (4.4%) in COPD patients without comorbidities (P < 0.05).
Conclusion: COPD patients with comorbidities had a higher prevalence of pulmonary fungal infection rate compared with COPD patients without comorbidities. Age, mechanical ventilation, corticosteroid therapy, and ICU admission were independent risk factors for pulmonary fungal infection in COPD patients with comorbidities.
Keywords:  Chronic Obstructive Pulmonary Disease (COPD), comorbidities, pulmonary fungal infection, Saboraud’s Dextrose Agar (SDA)

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782

Cite this article: Shukla, S., & Shukla, C.B. (2020). Role of Comorbidities in Establishment of Pulmonary Mycosis in Chronic Obstructive Pulmonary Disease Patients in and Around Rewa, Ind. J. Pure App. Biosci. 8(3), 114-122. doi: http://dx.doi.org/10.18782/2582-2845.7923