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Liposomes, consist of lipid vesicles which aqeous layer enclosed by phospholipid layer . Liposomes are
one of unique drug delivery system which can be use in controlling and targeting drug delivery system.
Liposomes, which are biodegradable and essentially non‐toxic vehicles, can encapsulate both hydrophilic
and hydrophobic materials, and are utilized as drug carriers in drug delivery systems which protwcts
drug from degradation. Liposomes can be filled with drugs, and used to deliver drugs for cancer and
other diseases Among several new drug delivery systems, liposomes characterize an advanced technology
to deliver active molecules to the site of action. Research on liposome technology has progressed from
conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained
by changing the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have
also been developed using several molecules, such as glycolipids or sialic acid. This review discusses the
potential applications of liposomes in drug delivery with examples of formulations approved for clinical
use,their preparation method, targeting, mechanism of formation, liposome component and the problems
associated with further exploitation of this drug delivery system.
Keywords: Lipsome,phospholipid,glycolipids.