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Gentamicin is an antibiotic that exhibits a broad spectrum of (Gram –ve) activity and is particularly valuable in several sepsis in animals and humans. Nephrotoxicity and ototoxicity has been recognized as a major complication of aminoglycoside antibiotics for many years. Gentamicin causes reversible renal impairment. The incidence of renal failure is 10-15 % (Naidu et al., 2000) and 10-20 % (Silan et al., 2007) of therapeutic courses. Antibiotics in the aminoglycoside class, such as gentamicin and tobramycin, may produce cochlea toxicity through a poorly understood mechanism (Dobie et al., 2006). The present study aims at studying the ototoxic effect of gentamicin at one high dose (40 mg/kg). The 24 Wistar Albino rats were divided into 4 equal groups (Control, Gentamicin group, curcumin at low and high dose group). The histopathological alterations reveal that the curcumin has reversible effect in gentamicin induced ototoxicity.

Keyword: Gentamicin, Ototoxicity, Curcumin