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Aspirin (acetylsalicylic acid, ASA) is a commonly prescribed drug with a wide pharmacological
spectrum. It is classified as the best non-steroidal anti-inflammatory drugs (NSAIDs). Inflammatory
processes may play a pivotal role in several pathogenesis such as osteoarthritis, cerebrovascular injury,
hypertension, auto-immune diseases and where oxidative stress plays also a major role. The present study
was designed to determine whether a dose of 30 mg/kg of ASA might prevent oxidative damages caused
by an intraperitonial injection of peroxide hydrogen (100 mg/kg). Antioxidant enzymatic activities of
catalase (CAT), superoxide dismutase (SOD), gluthation reductase (GR), succinate deshydrogenase
(SDH), and index of lipid peroxidation: malodialdehyde (MDA) were determined. Antioxidant biomarkers
significantly increased and mortality was noted with peroxide hydrogen (H2O2), which was significantly
suppressed by treatment with aspirin. These results suggest that ASA may exert protective effects against
oxidative stress damages.
Keywords: Acetylsalicylic acid (Aspirin), Oxidative stress, Antioxidant.