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Cyclophosphamide has been used for treatment of various cancers, hence there are side toxic effects has been noted hence studies were carried to evaluate the protective effects of Ginkgo biloba in germ cells of mice two experiments were carried out. In first experiment the animals were treated with various doses of GBE 200, 400 and 600 mg/kg were given orally. All the animals were killed on 60th day if treatment for meiotic prepares were made according to the standardized protocol. In second experiment animals were given Cyclophosphamide co administered with GBE for seven days prior to the cp . the prepared slides were screened for the presence of various types of aberrations such as autosomal univalent and sex chromosomal univalent and translocations in control and treated animals . the data was analyzed using standard statistical analysis the results showed increased incidence of chromosomal aberration in cp induced animals however in primed with GBE there is a significant reduction in the frequency of aberrations thus the data clearly indicate protective nature of Ginkgo biloba in Swiss albino mice the present observations are useful in ca cancer chemotherapy regimen.

Keywords: Cyclophosphamide, Ginkgo Biloba Extract, Chromosomal Aberrations, Germ Cells