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Despite significant breakthroughs in understanding, prevention, and treatment of prostate cancer, it still represents the fourth leading cancer in the general population worldwide. The high rate of mortality among prostate cancer patients is clear indication of insufficient efficiency of currently available prostate cancer therapies. Thus, there is a constant demand for new therapies or drugs to treat and prevent this life-threatening disease. Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. In this direction, medicinal herbs are nowadays looked to have great potential to act as chemopreventive agents. One such underutilized potential medicinal herb Asplenium ceterach is highly unexplored in Kashmir region. Therefore, the present investigation was undertaken to investigate the nutraceutical composition, antioxidant activity and preliminary anti-cancerous potential of this medicinal herb. The current study demonstrated aqueous extract of Asplenium ceterach (ACE) to be rich source of nutraceuticals like phenols (465 ± 1.49mg per 100g) and flavonoids (66.34 ± 0.351mg/ 100g) and possess strong antioxidant activity. This preliminary study demonstrated remarkable anti-cancerous activity of AC extract against two prostate cancer cell lines viz., PC3 and LNCaP. This research study provides a scientific basis for exploitation of Asplenium ceterach from Kashmir valley for its use for anti-cancer chemopreventive drug development or as an adjuvant to existing prostate cancer therapies. Keywords: Asplenium ceterach, Nutraceuticals, Anti-oxidant, Prostate cancer, Anti-cancer.