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Present study was designed on hypophosphatemic pregnant Murrah buffaloes of different age groups belonging to Malwa region of MP. 30 field clinical cases of hypophosphatemia were diagnosed and treated. The diagnosis was made by symptoms like history of passing coffee colored urine, reduced appetite and milk production followed by interpretation of Hemato-biochemical parameters which revealed high mean concentration of iron, molybdenum potassium, blood glucose, creatinine, bilirubin, blood urea nitrogen, total bilirubin, serum alkaline phosphatase, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), erythrocyte sedimentation rate (ESR), neutrophil and lymphocyte count . While significantly low concentration of glucose-6 phosphate dehydrogenase (G6PD), serum albumin, total protein, copper, red blood cells (RBC), hemoglobin (Hb) and packed cell volume (PCV) were found. The study was conducted on 40 animals, out of which 10 normal pregnant Murrah buffaloes placed in group A were included in study as control. The remaining 30 diseased animals were placed in group B which was further subdivided into two sub groups: sub group B1 comprising of 10 and sub group B2 of 20 diseased animals. All buffaloes of group B were treated with sodium acid phosphate with difference of dose. The sodium acid phosphate was given @ 3mg/kg twice a day for 7 days by i.v route to sub group B1 and @ 15 mg/kg twice a day for 7 days to sub group B2 buffaloes. The supportive therapy was same in duo groups. No signs of recovery were seen in sub group B1; however the recovery was seen in sub group B2 in which phosphorus was given at higher doses. In conclusion the administration of inorganic phosphorus @ dose rate of 15 mg/kg b .wt facilitated the recovery in hypophosphatemic pregnant Murrah buffaloes.

Key words: Hypophosphatemia, Hemoglobinurea, Murrah, Phosphorus