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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2018 , Volume 6, Issue 3
Page No. : 460-467
Article doi: : http://dx.doi.org/10.18782/2320-7051.6203
Anti-Diabetic Effects of Vanadium Pentoxide Nanoparticles in STZ-Induced Diabetic Rats
K. Vijay1*, R. Suresh2, K. Loganathasamy1, V. Narayanan2, V. Pandiyan1, T. Satheesh Kumar1 and K. Padmanath1
1Department of Veterinary Biochemistry, Madras Veterinary College, Vepery, Chennai 600007, T.N., India
2Department of Inorganic Chemistry, University of Madras, Guindy Maraimalai Campus, Chennai, T.N., India
*Corresponding Author E-mail: vijayvet88@gmail.com
Received: 28.01.2018 | Revised: 25.02.2018 | Accepted: 7.03.2018
ABSTRACT
The aim of the present study was to evaluate the anti-diabetic effects of vanadium pentoxide nanoparticles and to compare it with that of vanadium pentoxide on STZ-induced diabetic rats. Vanadium pentoxide and Nano-vanadium pentoxide each at the dose rate of 5 mg/kg body weight were administered orally in normal and experimentally induced diabetic rats for 30 days and glimepiride was used as a reference drug. Both the vanadium pentoxide and Nano-vanadium pentoxide significantly decreased the levels of serum glucose, triacylglycerol, total cholesterol, urea and creatinine and the activities of ALT and AST and significantly increased the serum protein and liver glycogen levels in diabetic rats. No adverse effect in gastrointestinal tract was observed. In the present study vanadium in the form of nanoparticle outperformed as an anti-diabetic agent than that of vanadium pentoxide in normalizing the biochemical parameters without any adverse effects.
Key words: Streptozotocin; Glucose; Vanadium; Nanoparticle; Hyperglycemia.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2320-7051.6203
Cite this article:
Vijay,K., Suresh, R., Loganathasamy, K., Narayanan, V., Pandiyan, V., Satheesh Kumar, T., and Padmanath, K., Anti-Diabetic Effects of Vanadium Pentoxide Nanoparticles in STZ-Induced Diabetic Rats, Int. J. Pure App. Biosci. 6(3): 460-467 (2018). doi: http://dx.doi.org/10.18782/2320-7051.6203
