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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2014 , Volume 2, Issue 1
Page No. : 223-230
Article doi: : http://dx.doi.org/10.18782
Antibacterial Activity of 1,2-Benzenediccarboxylic Acid, Dioctyl Ester Isolated from the Ethyl Acetate Soluble Sub-portion of the unripe Fruits of Nauclea latifolia
Fadipe, Labake Ajoke1*; Haruna, Kaita2 and Mohammed Ilyas3
1Department of Chemistry, Federal University of Technology, Minna, Nigeria
2Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria
3Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria
*Corresponding Author E-mail: labsfad @yahoo.com
ABSTRACT
A phytochemical and antibacterial study of the ethyl acetate soluble sub-portion of the methanol extract
of the unripe fruits of Nauclea latifolia (Family Rubiaceae) its fractions and sub-fractions led to the
isolation of 1, 2-benzenedicarboxylic acid, dioctyl ester for the first time from the unripe fruits of the
plant. The structure of the viscous golden yellow oil was elucidated using physical, chemical, literature
search and spectroscopic identification. The isolated compound (Me2-b1 at 100μg/ml) displayed
moderate inhibitory activity against Gram positive organisms tested, similar to that exhibited by
chloramphenicol against the organisms. The crude ethyl acetate soluble sub-portion Me, at 50mg/ml
exhibited significant broad spectrum activity, while one of its fractions (Me2 at 20mg/ml) and subfraction
(Me2-b at 20mg/ml) were moderately active against most of the test bacterial strains.
Key words: Nauclea latifolia unripe fruits, ethyl acetate soluble sub-portion, antibacterial, 1, 2-
benzenedicarboxylic acid, dioctyl ester.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article:
Int. J. Pure App. Biosci. 2 (1): 223-230 (2014)
