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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2018 , Volume 6, Issue 2
Page No. : 196-201
Article doi: : http://dx.doi.org/10.18782/2320-7051.6374
Assessment of DNA Damage by Alkaline Comet Assay in Occupationally Exposed Welders of Hyderabad, Telangana
Chandana Lakkaraju1*, Indira Priyadarshini2, Sridevi Tirumalaraju2, Srinivas Bandaru1, G. Deepika1 and Hema Prasad Mundluru1
1Institute of Genetics and Hospital for Genetic Diseases, Osmania University,
Begumpet, Hyderabad 500016, India
2Department of Genetics, Bhagwan Mahavir medical research centre, Hyderabad
*Corresponding Author E-mail: chandanalakkaraju@gmail.com
Received: 5.03.2018 | Revised: 1.04.2018 | Accepted: 7.04.2018
ABSTRACT
Welding work is one of the pervasive industrial profession in Hyderabad,Telangana. Pin-sized or no attention is usually focused at occupational health risk by local or state authorities in Hyderabad. The present work was aimed at the assessment of DNA damage in welding workers by Alkaline Comet Assay(Single cell gel electrophoresis) in blood lymphocytes. The results revealed that there was statistically significant difference between the level of DNA damage in blood lymphocytes of welders and control group (p < 0.05). In addition, the level of damage to DNA in blood of subjects with long term exposure and old age is of serious concern. There is the need to screen occupational activities that can pose serious health risks. The relative ignorance of the welding workers about the health risks they are exposed to as well as the public should be addressed.
Key words: Welding workers, Occupational exposure to welding fumes, DNA damage
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2320-7051.6374
Cite this article:
Lakkaraju C., Priyadarshini, I., Tirumalaraju, S., Bandaru, S., Deepika, G. and Mundluru, H.P., Assessment of DNA Damage by Alkaline Comet Assay in Occupationally Exposed Welders of Hyderabad, Telangana, Int. J. Pure App. Biosci. 6(2): 196-201 (2018). doi: http://dx.doi.org/10.18782/2320-7051.6374
