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Animals fed a high-fructose diet developclinical characteristics of metabolic syndrome; therefore,highfructose
fed animals are particularly useful for assessingpotential therapeutic interventions against
metabolic syndrome.In the present study we investigated the effect of Lactobacillus LP on hyperglycemia,
insulin resistance and hypertriglyceridemia in fructose drinking rats as a model of metabolic syndrome.
Male albino rats were given a15%fructose solution as drinking water for 13 weeks. Fructose solution
significantly increased the serum concentrations of glucose, triacylglycerols, VLDL-c and LDL-c in
comparison with control group. It also induced insulin resistance which expressed by HOMA-IR.
Administration of lactobacillus LB significantly improved the levels of serum glucose,triacylglycerols,
VLDL-c and LDL-c by (36%, 40.2%, 40.2% and 50%) respectively. It also significantly improved the
HOMA-IR by 56%. These results suggested the protective role of lactobacillus LB against the metabolic
syndrome associated disorders like hyperglycemia, insulin resistance and hyperlipidemia.
Keywords: metabolic syndrome, high fructose, probiotics.