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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2015 , Volume 3, Issue 1
Page No. : 11-17
Article doi: : http://dx.doi.org/10.18782
Comparison of specific recombinant proteins to Mycobacterium tuberculosis skin test in animal model
Wichit Thaveekarn1*, Narumol Pakmanee1, Sunutcha Suntrarachun1, Orawan Khow1 and Suthidee Petsong2
1Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand
2Department of Medical Microbiology, Chulalongkorn University, Thailand
ABSTRACT
Detection of tuberculosis infection by delayed-type hypersensitivity skin test with purified protein
derivative (PPD) antigen is still used in many countries including Thailand. The problems of this
technique are non-specific reactions in individuals who received BCG vaccination and false positive
result in previously exposed to non-tuberculous Mycobacteria (NTM) subjects. Several
Mycobacterial specific antigens that can distinguish Mycobacterium tuberculosis from BCG and
NTM such as ESAT-6, CFP-10, Rv2031c have been reported. This study found that combinedrecombinant
antigen consists of ESAT-6, CFP-10 and Rv2031c, gave good specific more than
individual antigen in distinguishing MTB infection from BCG vaccination by skin testing in guinea
pig.
Keywords: ESAT-6, CFP-10, Rv2031c, PPD, M. tuberculosis.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article:
Int. J. Pure App. Biosci. 3 (1): 11-17 (2015)
