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Microsponge technology has been introduced in topical drug products to facilitate the controlled
release of active drug into the skin in order to reduce systemic exposure and minimize local
cutaneous reactions to active drugs. Microsponge consists of macroporous beads, typically 10-25
micron in diameter, loaded with active agent. When applied to the skin, the microsponge releases its
active ingredients on a time mode and also in response to other stimuli. Microsponge drug delivery
technology holds a great promise for reaching the goal of controlled and site-specific drug delivery
and hence, has attracted wide attention of researchers. This article presents a broad review of
Microsponges delivery system discussing the principles and preparation methods. Appropriate
analytical techniques for characterization of Microsponges like Particle size and its distribution,
surface morphology, porosity, density are covered. These microsponges are used in the sunscreens,
creams, ointments, over-the-counter skin care preparations, which are meant for topical application.
Microsponge drug delivery can provide increased efficacy for topically active agents with enhanced
safety, extended product stability and improved aesthetic properties in an efficient and novel
manner. They are mostly used for topical use and have recently been used for oral administration.
Keywords: Microsponge, controlled release, Topical drug delivery,solvent diffusion method, Quasiemulsion.