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Chewable modified release tablets containing two active ingredients vitamin C (200mg) and Sodium
Fluoride (2mg) were formulated for the treatment of dental diseases. Other ingredients include
Mannitol, Carbopol and Hydroxyl-Propyl Methylcellulose (HPMC), in different ratios. These tablets
were prepared by direct mixing of Hydroxypropyl Methylcellulose (HPMC), vitamin C, Sodium
Fluoride, Carbopol, Mannitol and Magnesium Stearate by pressing through single punch machine.
Their dissolution properties were assessed using USP (paddle apparatus).In order to investigate the
mode of drug release from the tablets, the release data were subjected to various release kinetic
models. The modified release strength of the tablets was also evaluated. The results showed that the
combination of two polymers give a satisfactory drug release. This new formulation can be
administered either by swallowing the whole tablet or by chewing the tablet beacause controlled
release properties of this formulation do not change by chewing the tablet. Such type of tablets could
be valuable for all patients including those who have difficulty in swallowing, for example pediatrics
and geriatrics patients.
Keywords: Modified release tablets, HPMC, carbopol, pediatrics, geriatric, Modified release Property.