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The objective of the present study was to determine distribution and antibiotic susceptibility pattern
of bacterial strains isolated from patients suffering from UTI at tertiary health care centre in North
Bengal, with special reference to ESBL and MRSA producers. This health care centre was chosen
for the study as this centre is visited by patients from inside and outside the country. Moreover, this
health care centre is also visited by patients from neighboring countries like western part of
Bangladesh, Bhutan and Eastern Nepal. The present retrospective study was conducted from july
2013 to july 2014 where 457 uropathogens were isolated from 2090 consecutive urine samples.
Automated identification and susceptibility (AST) system that analyzed MIC patterns was used.
ESBL producers, their phenotypes and MRSA were identified. Results were analyzed using computer
software, specifically designed to evaluate the results generated by the automated system. The most
prevalent pathogens were Escherichia coli (48%) followed by Klebsiella spp (22%) and
Pseudomonas aeruginosa (5%). Majority of the isolates (59%) were from females. Prevalence of
ESBL and MRSA was found to be 33.26 % and 75% respectively. Higher than 80% resistance were
observed for broad-spectrum penicillin with an increasing resistance to third generation
cephalosporins and quinolone drugs. Tigegcycline was found to be effective against both gram
negative and gram positive uropathogen. Daptomycin and Colistin was found to be drug of choice
for both gram positive and for gram negative uropathogen respectively. The data highlights a
serious need to monitor the current trend of growing antibiotic resistance. It indicates that it is
imperative to rationalize the use of antimicrobials and employ them conservatively.
Keywords: Urinary tract infection, uropathogens, Antibiotic Resistance, ESBL, MRSA etc.