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Candida albicans is an opportunistic pathogen morphologically yeasts like fungi are responsible to
cause candidiasis in women of reproductive age. Therefore this present study focused on antifungal
activity of Prosopis gladulosa against Candida albicans strains isolated from patients. The samples
were isolated from the patients of admitted in the hospital at Erode. It was identified as Candida
albicans by the morphologically and biochemically tests from the 35 samples six different strains of
Candida albicans were isolated. The antifungal susceptibility tests were done against different
antifungal agents as the six isolated strains were resistant to Fluconazole, Itraconazole, Nystatin
and Clotrimazole, and it was found that all the strains were sensitive to Amphotericin B. The strain
4, 5, 6 are also sensitive Ketoconazole in addition to Amphotericin B therefore it was concluded that
all the six strains were multidrug resistant. The plant used in this was Prosopis gladulosa showed
antifungal against six different strains of Candida albicans. In that acetone extracts, methanol,
petroleum ether extract and water extract antifungal and increased with increase in concentrations.
Prosopis gladulosa aqueous extracts does not have much activity against Candida albicans strains.
Key words: Medicinal plant, Plant extracts, Alternative treatment, Prosopis gladulosa, Anti-yeast activity