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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2015 , Volume 3, Issue 4
Page No. : 72-78
Article doi: : http://dx.doi.org/10.18782
Acute oral toxicity activity of aqueous extract of Combretum glutinosum Perr. ex De leaves in wistar rats
Alowanou Goué G.1, Olounladé Abiodoun P.1,2*, Azando Erick Virgile B.1,3, Dossou Tobi R.1, Dedehou Vidjinnangni Fifamè Grâce N.1, Daga Florian D.1, Adenilé Adam D., Hounzangbé-Adoté Sylvie M.1
1Laboratoire d’Ethnopharmacologie et de Santé Animale, Faculté des Sciences Agronomiques, Université d’Abomey Calavi, 01 BP 526 Cotonou, Bénin
2Laboratoire Pluridisciplinaire, Ecole Nationale Supérieure des Sciences et Techniques Agronomiques, Université d’Agriculture de Kétou, BP : 95 Kétou, Bénin
3Ecole Nationale Supérieure des Sciences et Techniques Agronomiques de Djougou, Université de Parakou, Bénin
*Corresponding Author E-mail: abiodoun.olounlade@coraf.org
ABSTRACT
Combretum glutinosum Perr. ex is tropical and subtropical medicinal plant widely used in
traditional African to treat a range diseases such as parasitic diseases. The anthelmintic activity has
been demonstrated in previous studies. Toxicity acute evaluation of Combretum glutinosum aqueous
extract leaves was performed in this study, according to OECD 401 Guidelines for testing of
chemicals. A single dose of 2000 mg/kg bw were given in one single administration by gavage
female rats. No animal died and no behavioral signs of acute toxicity were observed. No statistically
significant differences (p>0,05), compared to control animals in the weight of animal, some organs
and the values of some hematological and biochemical parameters were observed. It was concluded
that the aqueous extract of C. glutinosum is safe for oral use at single dose of 2000 mg/kg bw. On
condition of chronic evaluation of the toxicity of the aqueous extract of C. glutinosum leaves, could
therefore be continuously used by small breeders to control small ruminant helminthes.
Key words: Acute toxicity, Combretum glutinosum, Rats; Aqueous extract, Veterinary medicine.
Full Text : PDF; Journal doi : http://dx.doi.org/10.18782
Cite this article:
Int. J. Pure App. Biosci. 3 (4): 72-78 (2015)
