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The present investigation was attempted to study the possible anti-genotoxic activity of crude Aegle
marmelos (AMF) fruit extract in cyclophosphamide-induced genotoxicity in mouse by using
chromosomal aberrations (CA’s) in germ cells and sperm morphology essay (SMA). Three different
doses of Aegles marmelos (200, 400, 600 mg/kg) were orally administered for their modulatory
capacity on the mutagenecity exerted by CP (50 mg/kg, i.p.). AMF alone did not induce any
significant variation in the incidence of CA’s and frequency of aberrant sperms. Pretreatment of
mice with AMF for 7 days and simultaneously with a single dose of cyclophosphamide significantly
reduced the frequency of CA’s and frequency of aberrant sperms, suggesting that the Aegles
marmelos fruit extractmodulates the CP induced genotoxicity in a dose dependent manner. Thus the
results clearly indicate the protective nature of Aegles marmelos fruit extract on cancer
chemoprevative strategy.
Key words: Aegle marmelos, Chromosomal Aberrations, Aberrant Sperms, Germ Cells.