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Indian Journal of Pure & Applied Biosciences (IJPAB)
Year : 2016 , Volume 4, Issue 1
Page No. : 15-23
Article doi: : http://dx.doi.org/10.18782/2320-7051.2189

Myocilin and Glaucoma its Risk Factors

Mahesh Kumar Lohano^1,2*, Li Su¹, Wang Ruochen¹, Buddha Bahdur Basnet¹, Hameem Naveed¹ Vash Dev Khemani², and Aijaz Ali Khooharo³

¹Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology,Wuhan 430074, China
²Liaquat University of Medical and Health Sciences, Jamshoro / Hyderabad
³Sindh Agriculture University Tandojam, Sindh, Pakistan
^*Corresponding Author E-mail: mklohana@yahoo.com
Received: 10.01.2016 | Revised: 22.01.2016 | Accepted: 26.01.2016

ABSTRACT

Myocilin (OMIM601652) MYOC gene, first revealed as a protein isolated from cultured human
Trabecular Meshwork (TM) cells after prolong dexamethasone treatment. Hence given the name
TIGR (Trabecular Meshwork Inducible Glucocorticoid Response Protein). The human myocilin
gene, a concealed acidic glycoprotein,contains 504 amino acids, positioned at chromosome
1(1q24.3 – 1q25.2), and filled with olfactomedin domain at its C terminus. Myocilin exists in various
tissues throughout the eye and many other organs. Mutant myocilin cause endoplasmic reticulum
pressure in eye angle tissues, including the trabecular meshwork, damaging the cells inside the
meshwork, ultimately leading to structural changes in the outflow pathway, and high intraocular
pressure.TM is vital in controlling pressure and mutations in MYOC.It has been recognized as the
cause of juvenile and adult onset of primary open angle glaucoma.
Keywords: Myocilin gene, glaucoma, Trabecular Meshwork, mutation.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2320-7051.2189

Cite this article:

Lohano, M.K., Su, L., Ruochen, W., Basnet, B.B., Naveed, H., Khemani, V.D., and Khooharo, A.A., Myocilin and Glaucoma its Risk Factors, Int. J. Pure App. Biosci. 4(1): 15-23 (2016). doi: http://dx.doi.org/10.18782/2320-7051.2189

No. 772, Basant Vihar, Kota

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