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Aquatic invertebrates are known to rely on innate immune mechanisms which include both
interacting cellular and humoral components to protect against potential pathogen .In the present
study aqueous, ethanol and chloroform extracts of freshwater mussel Lamellidens maginalis were
screened for antibacterial activity. The extracts were obtained from the whole body tissue of the
animals and tested against 5 pathogenic bacteria viz., Streptococcus pyrogenes, Staphylococcus
aureus, Serratia marganii, Klebsiella oxytoca and Lactobacillus vulgaris. The inhibition zone
ranged from 7mm to 13 mm. The minimum inhibition zone was 7mm, against K.oxytoca. The
maximum inhibition zone was 13 mm against L.vulgaris. Aqueous extract of L. maginalis showed
activities against the 5 bacterial strains. The maximum inhibition zone ranged from the 9 mm to
11mm. This data suggests that L.marginalis is the potential candidates for the isolation and
purification of potent antibiotics. Moreover, the extraction of the antimicrobial compound appeared
to be dependent on the extraction procedure and the nature of the solvents used for extraction.
Keywords: Lamellidens marginalis. Mollusc, Antibacterial activity, Pathogen, antimicrobial compound