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Mangos belong to the genus Mangifera of the family Anacardiaceae. The genus Mangifera contains
several species that bear edible fruit. Most of the fruit trees that are commonly known as mangos
belong to the species Mangifera indica. it has also been used for its medicinal value. In Samoa, a
bark infusion has been a traditional remedy for mouth infections in children (pala gutu), and in
Tonga, infusions of leaves of mango, the orange (Citrus sinensis), and other species are used to
make a potion to treat relapse sickness (kita). In India, a drink made from unripe mango fruit is used
as a remedy for exhaustion and heat stroke. Half-ripe fruit eaten with salt and honey is used for a
treatment of gastro-intestinal disorders, bilious disorders, blood disorders, and scurvy. Diabetes has
been treated with a drink made from the infusion of fresh mango leaves. Dried mango seed ground
into flour is used to treat diarrhea. Diarrhea and throat disorders are treated by gargling bark
extracts mixed with water. Fruit sap has been used to treat the pain of bee and scorpion stings1.
Many of the traditional Indian medicinal uses of mango involve eating unripe fruit. The present work
was accomplished to explore the cytotoxic potential of aqueous extract of Mangifera indica using
brine shrimp lethality bioassay method. In this methods, Mangifera indica showed a significant
activity. The cytotoxic activity of the extract was moderate having LC50 value of 5.05 μg/ml.
Key words: Brine shrimp, Cytotoxicity, Bark of Mangifera indica, Anacardiaceae.