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The sea slugs Plakobranchus ocellatus (Sacoglossa, Gastropoda) possess naturally photo synthetically active chloroplasts from ingested algae (functional kleptoplasts) in the epithelial cells of its digestive gland that is retained up to 10 months.). The present study aimed to evaluate the safety use of the acute toxicity of the crude ethanolic extract of Plakobranchus ocellatus that was evaluated by administration of the extract by intra peritoneal route to the female wistar rats. A single extract dose of 500, 1000, 1500, 2000, 2500, 3000 and 3500 mg/kg body weight) respectively and observed for 14 days. For sub-acute toxicity studiesthe most effective extracts of nudibranchwhich showed minimum toxic effect for the development of medicine was weighed and titrated slowly by using 2% Acacia gum till a uniform suspension was formed. On 28th day, the treated animals were sacrificed and blood samples were collected by orbital sinus. The organs such as liver, spleen, and kidney were processed to study, hematological and histopathological changes.
Keywords: Plakobranchus ocellatus (Sacoglossa, Gastropoda), acute and subacute toxicity Study.